Involve working the drug for weight loss, but with side effects

Therapy Phentermine topiramate for weight loss could be a useful treatment, but many can not tolerate the adverse side effects, an Australian study showed.

The study by Joseph Proietto of the University of Melbourne (photo) led a group of average weight of 13 kg for patients receiving a combination of very low energy diet of 15 mg of phentermine and 25 mg topiramate, under reduced 2010 and the 2012th

However, about 40% of the patients stopped the treatment, with many dropouts reported due to side effects such as cognitive changes, dry mouth, depression, and paresthesias. The mean duration of drug treatment of these patients was 10 months.

Those who were sold the drug is capable fell a further 6.7 kg and remained in treatment for at least 22 months.

Phentermine is a sympathomimetic agent that suppresses the appetite, topiramate has been used to treat epilepsy and migraine prophylaxis Australia. No drug has been approved for use in obesity, although the combined treatment was approved single pill known as drug Qsymia in the United States recently.

Prof Proeitto said dropout rates are much higher than the decrease 16% reported in controlled Qsymia in 2011, with a rate of fewer side effects studies.

He suggests that it may have something to do with the formulation of the drug, and the dose of 25 mg of topiramate in the original study was too high.

Halving the dose of 12.5 mg in a retrial of the combination therapy may help reduce some of the side effects, he said.

"For those who are able, phentermine topiramate continue, but the club will not only effective for the maintenance of weight loss, but also for the ongoing weight loss," the authors wrote in the journal of Australia.

Medical Journal of Australia 2014; in line

Therapy Phentermine topiramate for weight loss could be a useful treatment, but many can not tolerate the adverse side effects, an Australian study showed.
The study by Joseph Proietto of the University of Melbourne (photo) led a group of average weight of 13 kg for patients receiving a combination of very low energy diet of 15 mg of phentermine and 25 mg topiramate, under reduced 2010 and the 2012th
However, about 40% of the patients stopped the treatment, with many dropouts reported due to side effects such as cognitive changes, dry mouth, depression, and paresthesias. The mean duration of drug treatment of these patients was 10 months.
Those who were sold the drug is capable fell a further 6.7 kg and remained in treatment for at least 22 months.
Phentermine is ...